The metabolism of ring-labeled orotic acid in man.
نویسندگان
چکیده
Considerable knowledge concerning purine metabolism has been obtained from chemical and isotopic studies of urinary uric acid. Corresponding information in man is lacking for the closely related field of pyrimidine metabolism. The availability of ring-labeled orotic acid as a specific pyrimidine precursor (1), together with the presence of pseudouridine (5-ribosyluracil) and uracil, as specific end products of pyrimidine metabolism in man, in conveniently assayable amounts in human urine (2-4), makes it possible to conduct certain kinetic studies. In the present investigation the metabolism of ring-labeled orotic acid and the time course of isotope incorporation into urinary *pseudouridine and uracil were studied in order to develop methods of measurement and to obtain values for the whole-body rate of pyrimidine synthesis as well as for the turnover rate of certain ribonucleic acid fractions.
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 41 شماره
صفحات -
تاریخ انتشار 1962